Abstract
Objective: To investigate global longitudinal strain (GLS) of the left ventricle by echocardiography in patients with severe aortic valve stenosis and to analyze some factors related to GLS in the patient group. Research subjects and methods: Cross-sectional descriptive study on 45 patients diagnosed with severe aortic valve stenosis at Vietnam National Heart Institute (Bach Mai hospital), Hanoi from September 2022 to September 2023. Results: The average GLS was -14.1 ± 3.7% . In the group of patients with preserved EF, there were 18 patients (accounting for 62.1%) with reduced GLS (<16%), this result was 100% in the group with EF <50%. Factors such as the degree of diastolic failure, NT-proBNP, LDL-C are related to the GLS with p < 0.05. Through univariate analysis, we found that GLS has a close correlation with early diastolic mitral annulus velocity of the septum (septal E') with |R | =0.7, quite closely related to ejection fraction (EF) and left ventricular mass index (LVMI) with |R| are 0.58 and 0.56 respectively. Conclusion: Mean GLS in severe aortic valve stenosis patients was -14.1 ± 3.7%. In the preserved EF group there was a 62,1% reduction in GLS. Therefore, the GLS index changes earlier than EF, meaning that GLS should be measured to contribute to diagnosis, treatment and prognosis of patients.