Coenzyme Q10 and cardiovascular surgery

Đặng Vạn Phước; David Mantle

doi:10.58354/jvc.122.2026.1325

Home

BÀI TỔNG QUAN Issue: Số 122 - 2026 PHẪU THUẬT TIM MẠCH

Coenzyme Q10 and cardiovascular surgery

Published: September 28, 2026

10.58354/jvc.122.2026.1325

Abstract

Cardiovascular surgery, particularly when involving cardiopulmonary bypass, is associated with mitochondrial dysfunction, oxidative stress and inflammation. We have reviewed the potential benefit of supplementation with coenzyme Q10 (CoQ10) in patients undergoing cardiovascular surgery, given the role of CoQ10 in promoting normal mitochondrial function, and as an antioxidant and anti-inflammatory agent.

Keywords

cardiovascular surgery coenzyme Q10 ischaemia reperfusion injury mitochondrial dysfunction oxidative stress

References

Berman M, Erman A, Ben-Gal T, et al. Coenzyme Q10 in patients with end-stage heart failure awaiting cardiac transplantation: a randomized, placebo-controlled study. Clin Cardiol. 2004;27(5):295-299. doi:10.1002/clc.4960270512

DOI: doi.org/10.1002/clc.4960270512

Chello M, Mastroroberto P, Romano R, et al. Protection by coenzyme Q10 from myocardial reperfusion injury during coronary artery bypass grafting. Ann Thorac Surg. 1994;58(5):1427-1432. doi:10.1016/0003-4975(94)91928-3

DOI: doi.org/10.1002/clc.4960270512

Cherry AD. Mitochondrial dysfunction in cardiac surgery. Anesthesiol Clin. 2025;43(2):357-375. doi:10.1016/j.anclin.2025.02.004

DOI: doi.org/10.1016/0003-4975(94)91928-3

Crane FL. Biochemical functions of coenzyme Q10. J Am Coll Nutr. 2001;20(6):591-598. doi:10.1080/07315724.2001.10719063

DOI: doi.org/10.1016/0003-4975(94)91928-3

de Frutos F, Gea A, Hernandez-Estefania R, Rabago G. Prophylactic treatment with coenzyme Q10 in patients undergoing cardiac surgery: could an antioxidant reduce complications? A systematic review and meta-analysis. Interact Cardiovasc Thorac Surg. 2015;20(2):254-259. doi:10.1093/icvts/ivu334

DOI: doi.org/10.1016/j.anclin.2025.02.004

Ferreira LO, Vasconcelos VW, Lima JS, et al. Biochemical changes in cardiopulmonary bypass in cardiac surgery: new insights. J Pers Med. 2023;13(10):1506. doi:10.3390/jpm13101506

DOI: doi.org/10.1016/j.anclin.2025.02.004

Gvozdjáková A, Kucharská J, Mizera S, et al. Coenzyme Q10 depletion and mitochondrial energy disturbances in rejection development in patients after heart transplantation. Biofactors. 1999;9:301-306. doi:10.1002/biof.5520090227

DOI: doi.org/10.1002/biof.5520090227

Hyslop K, Ki KK, Naidoo R, et al. Cell-free mitochondrial DNA may predict the risk of post-operative complications and outcomes in surgical aortic valve replacement patients. Sci Rep. 2025;15(1):15857. doi:10.1038/s41598-025-00382-y

DOI: doi.org/10.1080/07315724.2001.10719063

Juricic S, Klac J, Stojkovic S, et al. Molecular and cellular mechanisms of myocardial ischemia and reperfusion injury: a narrative review. Cells. 2026;15(3):265. doi:10.3390/cells15030265

DOI: doi.org/10.1093/icvts/ivu334

10.

Karlsson J, Liška J, Gunnes S, et al. Heart muscle ubiquinone and plasma antioxidants following cardiac transplantation. J Mol Med. 1993;71:S76-S83. doi:10.1007/BF00226845

DOI: doi.org/10.1093/icvts/ivu334

11.

Karlsson J, Semb B. Heart muscle and plasma vitamin Q with heart transplantation. Can J Cardiol. 1997;13:147-152.

DOI: doi.org/10.3390/jpm13101506

12.

Kucharská J, Gvozdjáková A, Mizera S, et al. Coenzyme Q10 and alpha tocopherol in patients after heart transplantation. Bratisl Lek Listy. 1996;97:603-606.

DOI: doi.org/10.3390/jpm13101506

13.

Makhija N, Sendasgupta C, Kiran U, et al. The role of oral coenzyme Q10 in patients undergoing coronary artery bypass graft surgery. J Cardiothorac Vasc Anesth. 2008;22(6):832-839. doi:10.1053/j.jvca.2008.03.007

DOI: doi.org/10.1002/biof.5520090227

14.

Manghelli JL, Kelly MO, Carter DI, et al. Pericardial mitochondrial DNA levels are associated with atrial fibrillation after cardiac surgery. Ann Thorac Surg. 2021;111(5):1593-1600. doi:10.1016/j.athoracsur.2020.07.011

DOI: doi.org/10.1002/biof.5520090227

15.

Ogunro PS, Ogungbamigbe TO, Muhibi MA. The influence of storage period on the antioxidants level of red blood cells and the plasma before transfusion. Afr J Med Med Sci. 2010;39(2):99-104.

DOI: doi.org/10.1038/s41598-025-00382-y

16.

Orlando P, Sabbatinelli J, Silvestri S, et al. Ubiquinol supplementation in elderly patients undergoing aortic valve replacement: biochemical and clinical aspects. Aging (Albany NY). 2020;12(15):15514-15531. doi:10.18632/aging.103742

DOI: doi.org/10.1038/s41598-025-00382-y

17.

Rong Z, Tu P, Xu P, et al. The mitochondrial response to DNA damage. Front Cell Dev Biol. 2021;9:669379. doi:10.3389/fcell.2021.669379

DOI: doi.org/10.3390/cells15030265

18.

Rosenfeldt F, Marasco S, Lyon W, et al. Coenzyme Q10 therapy before cardiac surgery improves mitochondrial function and in vitro contractility of myocardial tissue. J Thorac Cardiovasc Surg. 2005;129(1):25-32. doi:10.1016/j.jtcvs.2004.03.034

DOI: doi.org/10.3390/cells15030265

19.

Saeed A, Al-Awamleh NA, Jain H, et al. Effects of coenzyme Q10 on postoperative arrhythmias and outcomes in cardiac surgery: a systematic review and meta-analysis. J Am Coll Cardiol. 2025;85(12)(suppl A).

DOI: doi.org/10.1007/bf00226845

20.

Tanaka J, Tominaga R, Yoshitoshi M, et al. Coenzyme Q10: the prophylactic effect on low cardiac output following cardiac valve replacement. Ann Thorac Surg. 1982;33(2):145-151. doi:10.1016/S0003-4975(10)61900-5

DOI: doi.org/10.1007/bf00226845

21.

Zakkar M, Guida G, Suleiman MS, Angelini GD. Cardiopulmonary bypass and oxidative stress. Oxid Med Cell Longev. 2015;2015:189863. doi:10.1155/2015/189863

DOI: doi.org/10.1155/2015/189863

22.

Zhang J, Xu S, Xu Y, et al. Relation of mitochondrial DNA copy number in peripheral blood to postoperative atrial fibrillation after isolated off-pump coronary artery bypass grafting. Am J Cardiol. 2017;119(3):473-477. doi:10.1016/j.amjcard.2016.10.017

DOI: doi.org/10.1016/j.amjcard.2016.10.017

23.

Zhao RZ, Jiang S, Zhang L, Yu ZB. Mitochondrial electron transport chain, ROS generation and uncoupling. Int J Mol Med. 2019;44(1):3-15. doi:10.3892/ijmm.2019.4188

DOI: doi.org/10.3892/ijmm.2019.4188

24.

Zong Y, Li H, Liao P, et al. Mitochondrial dysfunction: mechanisms and advances in therapy. Signal Transduct Target Ther. 2024;9(1):124. doi:10.1038/s41392-024-01839-8.

DOI: doi.org/10.1038/s41392-024-01839-8

Tác giả

Đặng Vạn Phước: Đại học Y Dược Thành phố Hồ Chí Minh; David Mantle: Pharma Nord;

Files

PDF

Article Views104

Document Views0

Downloads14

Section BÀI TỔNG QUAN

Issue Số 122 - 2026

Category PHẪU THUẬT TIM MẠCH

Pages 22-27

Article detail

Coenzyme Q10 and cardiovascular surgery

Abstract

References

Tác giả

Files

Related articles

Analysis of Perioperative Cardiovascular Medication Use in Surgical Patients Undergoing Non-Cardiac Surgery at Hanoi Medical University Hospital

Trích dẫn bài báo

Tìm kiếm bài báo