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BÀI TỔNG QUAN Issue: Số 107S TIM MẠCH DỰ PHÒNG

Genomic and proteomic technologies in cardiology

Kim Ngọc Thanh: Trường Đại học Y Hà Nội; Trương Thanh Hương: Trường Đại học Phenikaa; Nguyễn Lân Việt: Nguyên Hiệu trưởng Trường Đại học Y Hà Nội; Nguyên Viện trưởng Viện Tim mạch Việt Nam; Phó Chủ tịch Thường trực Hội Tim mạch học Việt Nam;
Published: January 20, 2024
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Abstract

Genomic and proteomic technologies have become integral components of precision medicine, revolutionizing the field of cardiovascular disease management. These advanced technologies play a crucial role in enhancing screening accuracy, risk stratification, and the development of precise drugs and treatments for heart-related diseases. By leveraging gene and protein profile data, these technologies enable a more profound understanding of cardiovascular diseases, leading to more effective prevention and treatment strategies. Moreover, they facilitate the identification of individual genotype-phenotype differences, allowing for the creation of tailored cardiovascular prevention plans. Additionally, gene and protein technology holds promise in the development of novel drugs specifically designed to target complex, genetic cardiovascular diseases. However, it is important to exercise caution when applying gene and protein technology in cardiology, considering factors such as accuracy, cost, and accessibility. This article provides a comprehensive overview of the current and potential applications of gene and protein technology in managing and improving cardiovascular disease outcomes.

Keywords
genomics proteomics precision medicine cardiovascular diseases

References

1.
Antman EM, Loscalzo J. Precision medicine in cardiology. Nat Rev Cardiol. 2016;13(10):591-602. doi:10.1038/nrcardio.2016.101
2.
Li C, Pan Y, Zhang R, et al. Genomic Innovation in Early Life Cardiovascular Disease Prevention and Treatment. Circ Res. 2023;132(12):1628-1647. doi:10.1161/CIRCRESAHA.123.321999
3.
Mokou M, Lygirou V, Vlahou A, Mischak H. Proteomics in cardiovascular disease: recent progress and clinical implication and implementation. Expert Rev Proteomics. 2017;14(2):117-136. doi:10.1080/14789450.2017.1274653
4.
Leopold JA, Loscalzo J. Emerging Role of Precision Medicine in Cardiovascular Disease. Circ Res. 2018;122(9):1302-1315. doi:10.1161/CIRCRESAHA.117.310782
5.
O'Sullivan JW, Raghavan S, Marquez-Luna C, et al. Polygenic Risk Scores for Cardiovascular Disease: A Scientific Statement From the American Heart Association. Circulation. 2022;146(8):e93-e118. doi:10.1161/CIR.0000000000001077
6.
Visseren FLJ, Mach F, Smulders YM, et al. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice [published correction appears in Eur Heart J. 2022;43(42):4468]. Eur Heart J. 2021;42(34):3227-3337. doi:10.1093/eurheartj/ehab484
7.
Arnett DK, Blumenthal RS, Albert MA, et al. 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines [published correction appears in Circulation. 2019;140(11):e649-e650] [published correction appears in Circulation. 2020;141(4):e60] [published correction appears in Circulation. 2020;141(16):e774]. Circulation. 2019;140(11):e596-e646. doi:10.1161/CIR.0000000000000678
8.
Sopic M, Vilne B, Gerdts E, et al. Multiomics tools for improved atherosclerotic cardiovascular disease management. Trends Mol Med. 2023;29(12):983-995. doi:10.1016/j.molmed.2023.09.004
9.
Musunuru K, Hershberger RE, Day SM, et al. Genetic Testing for Inherited Cardiovascular Diseases: A Scientific Statement From the American Heart Association. Circ Genom Precis Med. 2020;13(4):e000067. doi:10.1161/HCG.0000000000000067
10.
Nurmohamed NS, Kraaijenhof JM, Mayr M, et al. Proteomics and lipidomics in atherosclerotic cardiovascular disease risk prediction. Eur Heart J. 2023;44(18):1594-1607. doi:10.1093/eurheartj/ehad161
11.
Haslam DE, Li J, Dillon ST, et al. Stability and reproducibility of proteomic profiles in epidemiological studies: comparing the Olink and SOMAscan platforms. Proteomics. 2022;22(13-14):e2100170. doi:10.1002/pmic.202100170
12.
Ganz P, Heidecker B, Hveem K, et al. Development and Validation of a Protein-Based Risk Score for Cardiovascular Outcomes Among Patients With Stable Coronary Heart Disease. JAMA. 2016;315(23):2532-2541. doi:10.1001/jama.2016.5951
13.
Williams SA, Ostroff R, Hinterberg MA, et al. A proteomic surrogate for cardiovascular outcomes that is sensitive to multiple mechanisms of change in risk. Sci Transl Med. 2022;14(639):eabj9625. doi:10.1126/scitranslmed.abj9625
14.
Olivotto I, Oreziak A, Barriales-Villa R, et al. Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): a randomised, double-blind, placebo-controlled, phase 3 trial [published correction appears in Lancet. 2020;396(10253):758]. Lancet. 2020;396(10253):759-769. doi:10.1016/S0140-6736(20)31792-X
15.
Schmidt AF, Carter JL, Pearce LS, et al. PCSK9 monoclonal antibodies for the primary and secondary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2020;10(10):CD011748. doi:10.1002/14651858.CD011748.pub3
16.
Schwartz GG, Steg PG, Szarek M, et al. Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome. N Engl J Med. 2018;379(22):2097-2107. doi:10.1056/NEJMoa1801174
17.
Sabatine MS, Giugliano RP, Keech AC, et al. Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease. N Engl J Med. 2017;376(18):1713-1722. doi:10.1056/NEJMoa1615664
18.
Zhang H, Liao M, Cao M, et al. ATRQβ-001 Vaccine Prevents Experimental Abdominal Aortic Aneurysms. J Am Heart Assoc. 2019;8(18):e012341. doi:10.1161/JAHA.119.012341
19.
Dai Y, Chen X, Song X, et al. Immunotherapy of Endothelin-1 Receptor Type A for Pulmonary Arterial Hypertension. J Am Coll Cardiol. 2019;73(20):2567-2580. doi:10.1016/j.jacc.2019.02.067
20.
Zhao Z, Chen Y, Francisco NM, et al. The application of CAR-T cell therapy in hematological malignancies: advantages and challenges. Acta Pharm Sin B. 2018;8(4):539-551. doi:10.1016/j.apsb.2018.03.001
21.
Ray KK, Wright RS, Kallend D, et al. Two Phase 3 Trials of Inclisiran in Patients with Elevated LDL Cholesterol. N Engl J Med. 2020;382(16):1507-1519. doi:10.1056/NEJMoa1912387
22.
Raal FJ, Santos RD, Blom DJ, et al. Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial. Lancet. 2010;375(9719):998-1006. doi:10.1016/S0140-6736(10)60284-X
23.
Liu N, Olson EN. CRISPR Modeling and Correction of Cardiovascular Disease. Circ Res. 2022;130(12):1827-1850. doi:10.1161/CIRCRESAHA.122.320496
Genomic and proteomic technologies in cardiology

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Section BÀI TỔNG QUAN
Issue Số 107S
Category TIM MẠCH DỰ PHÒNG
Pages 153-162
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