Abstract
Overview: Many studies have demonstrated that the rs207074 gene NOS3 polymorphism is related to the progression of cardiovascular disease. Objectives: Survey rs2070744 gene NOS3 polymorphism in hypertensive patients with heart failure and reduced ejection fraction at Bac Lieu Provincial General Hospital, 2023 - 2024. Methods: Cross-sectional descriptive study Out of a total of 45 patients diagnosed with hypertension according to the Vietnam Heart Association and heart failure with EF <40% according to ESC 2022, hospitalized for treatment at Bac Lieu General Hospital from April 2023 to April 2024. Results: 86.7% of subjects in the study were classified as NYHA III when hospitalized, 97.8% of patients had a history of chronic coronary syndrome, 33.3% had a history of diabetes. The rate of readmission during 6 months of follow-up was 28.9%. Regarding NOS3 gene rs207074 polymorphism: TT genotype accounts for the highest proportion with 71.1%, followed by CT with 26.7%, only 2.2% of patients have CC genotype. The study did not record a statistically significant association of genetic polymorphisms with age, gender, BMI as well as heart failure grade, history, and hospital readmission characteristics of the study subjects (p>0.05). Conclusion: The study is still limited in sample size; the results have not found an association of the NOS3 gene rs207074 polymorphism with cardiovascular risk factors in hypertensive patients with heart failure and reduced ejection fraction at the General Hospital. Faculty of Bac Lieu province.