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NGHIÊN CỨU LÂM SÀNG Issue: Số 111 BỆNH MẠCH VÀNH

Frequency and characteristics of Aspirin and Clopidogrel resistance using the VerifyNow test in patients undergoing percutaneous coronary intervention: a cross-sectional, single-center study

Vũ Hoàng Vũ: Đại học Y Dược TP. Hồ Chí Minh; Nguyễn Dương Khang: Bệnh viện Đại học Y Dược TP. Hồ Chí Minh; Võ Thị Diễm Thúy: Bệnh viện Đại học Y Dược TP. Hồ Chí Minh; Trương Quang Bình: Đại học Y Dược TP. Hồ Chí Minh;
Published: August 31, 2024
Views: 139
DOI 10.58354/jvc.111.2024.834

Abstract

Overview: Personalized treatment in cardiovascular diseases is an inevitable trend in practice. The VerifyNow test for assessing aspirin and clopidogrel response is a promising tool in terms of effectiveness and high availability.

Objective: To report the frequency of poor response to aspirin and clopidogrel in a population of patients undergoing percutaneous coronary intervention.

Method: A descriptive cross-sectional study, conducted from August 2022 to March 2023 at the Department of Interventional Cardiology, University Medical Center of Ho Chi Minh City

Results: Among 100 patients participating in the study, 9 patients did not respond to aspirin, 17 patients did not respond to clopidogrel. There were 3 patients who did not respond to both aspirin and clopidogrel.

Conclusion: VerifyNow is a quick and effective test in identifying groups that do not respond to aspirin and clopidogrel. Larger studies are needed to determine the role of the VerifyNow test in clinical practice.

References

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Yaseen IF, Farhan HA, Abbas HM. Clopidogrel non-responsiveness in patients undergoing percutaneous coronary intervention using the VerifyNow test: frequency and predictors. Eur J Hosp Pharm. 2019;26(2):113-116. doi:10.1136/ejhpharm-2017-001359
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Stone GW, Witzenbichler B, Weisz G, et al. Platelet reactivity and clinical outcomes after coronary artery implantation of drug-eluting stents (ADAPT-DES): a prospective multicentre registry study. Lancet. 2013;382(9892):614-623. doi:10.1016/S0140-6736(13)61170-8
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Welsh KJ, Dasgupta A, Nguyen AN, et al. Utility of VerifyNow for Point-of-Care Identification of an Aspirin Effect Prior to Emergency Cardiac Surgery. Ann Clin Lab Sci. 2015;45(4):377-381.
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Price MJ, Angiolillo DJ, Teirstein PS, et al. Platelet reactivity and cardiovascular outcomes after percutaneous coronary intervention: a time-dependent analysis of the Gauging Responsiveness with a VerifyNow P2Y12 assay: Impact on Thrombosis and Safety (GRAVITAS) trial. Circulation. 2011;124(10):1132-1137. doi:10.1161/CIRCULATIONAHA.111.029165
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Mitchell DL, McGuire LS, Khalid SI, et al. Assessing the efficacy of VerifyNow platelet-function testing in predicting postoperative thromboembolic complications of neuroendovascular surgery: A systematic review and meta-analysis (part 1). Interv Neuroradiol. doi:10.1177/15910199231224008

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Section NGHIÊN CỨU LÂM SÀNG
Issue Số 111
Category BỆNH MẠCH VÀNH

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