Abstract
Aim: Evaluating Left ventricular global longitudinal strain (LVGLS) and its relationship with 2D echocardiographic parameters.
Method: We conduct a controlled, prospective, descriptive cross-sectional study. We included 52 patients with Basedow's disease diagnosed by serum FT4 and TSH from August 2022 to August 2023 and 42 healthy control volunteers from Bach Mai Hospital. We then used EchoPAC 110.1.2; GE Healthcare to analyze speckle tracking results on 2-dimensional echocardiography.
Results: The age, sex and BMI distributions were similar between the groups. The mean TSH and FT4 concentrations of the Basedow's disease group were 0,007 ± 0,011 µU/mL and 59,00 ± 26,43 pmol/L, respectively. The mean heart rate and blood pressure of the control group were statistically significantly higher. The LVGLS in Basedow's disease patients in 2 chamber view, 3 chamber view, 4 chamber view and global longitudinal strain average were -20,7 ± 2,61%, -20,64 ± 2,63%, -20,77 ± 2,22%, -20,70 ± 2,23%, respectively, significantly lower (p < 0,001) than those of the control group. Furthermore, LVGLS in the Basedow's disease group was related to serum FT4 (p < 0,05) and inversely correlated to ejection fraction assessed by Simpson’s biplane (r = -0,305, p < 0,05).
Conclusion: Left ventricular global longitudinal strain (LVGLS) was lower in the Basedow's disease group. It was related to serum FT4 and positively correlated to ejection fraction assessed by Simpson’s biplane.