Abstract
Introduction: Numerous studies worldwide have demonstrated the correlation between different blood lipid indices and the severity of coronary artery disease, as measured by scales such as Gensini and SYNTAX. However, data on the role of non-HDL-C/HDL-C ratio in predicting the severity of coronary artery disease is limited.
Objective: To describe the relationship between non-HDL-C/HDL-C ratio and the severity of coronary artery disease.
Study population: We evaluated 220 patients diagnosed with non-ST-segment elevation acute coronary syndrome who underwent coronary angiography.
Study design: This was a cross-sectional descriptive study.
Results: In the study population, the mean age was 65,5±11 years and male gender predominated (59.1%). The mean non-HDL-C concentration was 146,5±48,7 mg/dL, and the non-HDL-C/HDL-C ratio was 4,4±1,8. The Gensini score was non-normally distributed, with a median value of 18 and interquartile range of 8-43. The study showed significant differences in age, systolic blood pressure, left ventricular ejection fraction, and GRACE score among the severity groups based on the Gensini score. As for lipid indices, significant differences were found in HDL-C concentration and non-HDL-C/HDL-C ratio among the severity groups of coronary artery disease. The group with a high Gensini score had higher HDL-C concentration and non-HDL-C/HDL-C ratio (p <0,05). LDL-C, HDL-C, non-HDL-C, and non-HDL-C/HDL-C ratio were not significantly correlated with Gensini score.
Conclusion: Our study demonstrated that patients with non-ST-segment elevation acute coronary syndrome had significantly higher non-HDL-C/HDL-C ratio in the group with a high Gensini score than in the low Gensini score group. The non-HDL-C/HDL-C ratio was not significantly correlated with the Gensini score.