Abstract
Objectives: Left ventricular diastolic dysfunction is the earliest and most common manifestation in heart of hypertension-mediated organ damage. This condition causes changes in the electrocardiogram, but little is known about it. This study aims to evaluate the perfomance of some electrocardiographic parameters in the diagnosis of left ventricular diastolic dysfunction in patients with primary hypertension.
Subjects and methods: This is a cross-sectional study, including 169 patients at the Vietnam Heart Institute. All study subjects had standard 12-lead electrocardiogram and were divided into 2 groups based on echocardiographic results to diagnose left ventricular diastolic dysfunction (85 patients) and normal left ventricular diastolic function (84 patients).
Results: Tend-P and Tend-Q intervals are independent factors associated with left ventricular diastolic dysfunction (p < 0.05). Diagnosis of left ventricular diastolic dysfunction with Tend-P interval at cut off value ≤ 275 ms with sensitivity 69.4%, specificity 70.2%, AUC 0.7; with Tend-Q interval at cut off value ≤ 442 ms with sensitivity 64.7%, specificity 67.9%, AUC 0.66. When combined with other factors, the diagnostic perfomance of left ventricular diastolic dysfunction of the Tend-P/ index (PQ x age) < 0.0282 has a sensitivity of 85.9%, a specificity of 76, 2%, AUC 0.81 and Tend-Q/(PQx age) <0.0443 have sensitivity 84.7%, specificity 76.2%, AUC 0.8.
Conclusions: The two indexes Tend-P/ (PQ x age) and Tend-Q/ (PQ x age) demonstrates a high perfomance for the diagnosis of left ventricular diastolic dysfunction.