Abstract
Objective: To evaluate the associations between selected clinical, laboratory, and echocardiographic parameters and reduced left ventricular global longitudinal strain (GLS) in patients with metabolic syndrome. Methods: A cross-sectional descriptive study was conducted on 74 patients diagnosed with metabolic syndrome according to the NCEP ATP III criteria at the Department of Cardiology, Viet Tiep Friendship Hospital, between January 2026 and June 2026. Results: The mean age of the study population was 68.11 ± 10.24 years, with females accounting for the majority of participants. Metabolic risk factors included a mean body mass index (BMI) of 24.89 ± 3.47 kg/m², waist circumference of 92.59 ± 9.82 cm, systolic blood pressure of 149.93 ± 25.38 mmHg, and triglyceride level of 3.13 ± 6.41 mmol/L. Left ventricular systolic function was preserved, with a mean left ventricular ejection fraction (LVEF) of 67.72 ± 6.30%, whereas the mean GLS was -18.98 ± 2.34%. Correlation analysis demonstrated that mean GLS was positively correlated with metabolic risk factors, with waist circumference showing the strongest correlation (r = 0.32, p = 0.006). Biplane LVEF showed a moderate inverse correlation with mean GLS (r = -0.59, p < 0.001). In univariable logistic regression analysis, body weight (OR = 1.06, p = 0.01), BMI (OR = 1.15, p = 0.02), waist circumference (OR = 1.08, p = 0.01), systolic blood pressure (OR = 1.03, p = 0.01), triglyceride level (OR = 1.69, p = 0.01), and biplane LVEF (OR = 0.85, p = 0.01) were significantly associated with reduced GLS. After adjustment in the multivariable logistic regression model, systolic blood pressure, waist circumference, triglyceride level, and biplane LVEF remained independently associated with reduced GLS (all p < 0.05). Conclusion: In patients with metabolic syndrome, biplane left ventricular ejection fraction (LVEF) showed a moderate inverse correlation with left ventricular global longitudinal strain (GLS), whereas waist circumference, body weight, body mass index (BMI), and triglyceride levels were positively correlated with GLS.
