Abstract
Structural heart interventions have evolved from shunt modification and balloon valvuloplasty into a broad catheter-based therapeutic ecosystem encompassing valvular, congenital, and selected heart-failure-related disorders. This narrative review examines the emergence of the field, historical milestones, contemporary evidence, and future directions. Transcatheter aortic valve implantation has the most mature randomized and long-term evidence, whereas mitral and tricuspid interventions and left atrial appendage occlusion require careful interpretation according to disease phenotype, anatomy, timing, and competing risks. Recent studies refine our understanding of valve durability, earlier intervention, heart failure outcomes, and antithrombotic strategies. Future frontiers include lifetime management, myocardial preservation, artificial intelligence, patient-specific simulation, transcatheter electrosurgery, biological disease modification, and patient-centered trial design. Sustainable progress requires linking technological innovation to demonstrable clinical benefit, equitable access, and multidisciplinary expertise.