Abstract
Objective: To investigate N-terminal pro B-type natriuretic peptide levels in patients with acute heart failure and type 2 diabetes mellitus and to identify associated factors. Subjects and Methods: A descriptive cross-sectional study was conducted on 72 patients with type 2 diabetes mellitus admitted for acute heart failure at Cardiovascular Institute Bach Mai Hospital from August 2024 to August 2025. Results: The mean N-terminal pro B-type natriuretic peptide levels were 8102,7 ± 7438,0 pg/ml. The mean NT-proBNP was higher in patients with reduced left ventricular ejection fraction, older age, female sex, more severe New York Heart Association class, larger left ventricular end-diastolic diameter, renal impairment, and insulin therapy; and lower in those with glycated hemoglobin below 7% and those treated with sodium–glucose cotransporter-2 inhibitors. Multivariate regression showed that N-terminal pro B-type natriuretic peptide independently increased with age (β = +153.4), left ventricular end-diastolic diameter (β = +350.4), and insulin therapy (β = +3,587.1), and decreased with sodium–glucose cotransporter-2 inhibitors (β = −3,610.6). Conclusions: N-terminal pro B-type natriuretic peptide tended to be elevated in patients with acute heart failure and reduced ejection fraction, poor glycemic control, and was influenced by age, renal function, and antidiabetic therapy.
