Abstract
Objective: To determine the relationship of serum hs-Troponin I after first acute myocardial infarction with left ventricular ejection fraction by transthoracic echocardiography.
Methods: A total of 103 patients of acute myocardial infarction were included in the descriptive cross-sectional process study. Hs-Troponin I concentration was measured by ELISA method and echocardiographic ejection fraction was calculated by modified Simpson’s rule. Echocardiographic ejection fraction was compared with serum troponin I concentration. Patients with previous myocardial infarction and non-cardiac causes of troponin elevation were excluded.
Result: There was strong negative correlation between hs-troponin I concentration and left ventricular ejection fraction, with an increasing troponin level, there was a fall in ejection fraction. The Pearson’s correlation coefficient was -0,66 which was statistically significant (p=0.0007). In our study, we observed that patients with ejection fraction <50% (left ventricular systolic dysfunction) were having post-procdural cTnI levels ≥21892 ng/L. Therefore a presumptive cut off level of cTnI ≥21892 ng/L may be taken to consider left ventricular systolic dysfunction in STEMI, with the value of AUC is 0.7 and the sensitivity, the specificity of this value is: 83.7% and 52.9%, respectively.
Conclusion: There was strong negative correlation between hs-troponin I concentration and left ventricular ejection fraction in patients presenting for the first acute ST elevation myocardial infarction. Thus, Troponin I can be used as a predictive test of left ventricular systolic function (EF) measured by Simpson's rule and transthoracic echocardiography. The level of hs-Troponin I ≥ 21892 ng/L may be taken to predict the state of left ventricular dysfunction with the sensitivity of this value is 83,7% and the
specificity is 52.9%.